Small molecules which reverse sickle cell anemia
Canned Analysis
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General Information
AccessionDCA00010243
TitleSmall molecules which reverse sickle cell anemia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the sickle cell anemia gene expression signature in the peripheral blood cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1bf5be467bea600fb847c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:505
Cell Typeperipheral blood
DO IDDOID:10923
Disease Namesickle cell anemia
Organismhuman
UMLS CUIC0019034
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM419145, GSM419146, GSM419147, GSM419148, GSM419149
Perturbed SamplesGSM419150, GSM419151, GSM419152, GSM419153, GSM419154
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE16728
Gene Expression Omnibus
Characterization of whole blood gene expression profiles in sickle-cell disease patients using globin mRNA reduction
21
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