Small molecules which reverse Down syndrome
Canned Analysis
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General Information
AccessionDCA00010293
TitleSmall molecules which reverse Down syndrome
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the Down syndrome gene expression signature in the soleus muscle, in the basal state, from five-month-old Ts65Dn Down syndrome (DS) males cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1c401e467bea600fb86b4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDdz:529
Cell Typesoleus muscle, in the basal state, from five-month-old Ts65Dn Down syndrome (DS) males
DO IDDOID:14250
Disease NameDown syndrome
Organismmouse
UMLS CUIC0013080
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM957176, GSM957177, GSM957178, GSM957179
Perturbed SamplesGSM957172, GSM957173, GSM957174, GSM957175
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE39159
Gene Expression Omnibus
Ts65Dn aneuploidy model of Down syndrome: skeletal muscle
7
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