Small molecules which mimic schizophrenia
Canned Analysis
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General Information
AccessionDCA00010312
TitleSmall molecules which mimic schizophrenia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the schizophrenia gene expression signature in the PBMC (peripheral blood mononuclear cells) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1c148e467bea600fb8572
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:548
Cell TypePBMC (peripheral blood mononuclear cells)
DO IDDOID:5419
Disease Nameschizophrenia
Organismhuman
UMLS CUIC0220702
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM677126, GSM677127, GSM677128, GSM677129, GSM677130, GSM677131, GSM677132, GSM677133, GSM677148, GSM677149, GSM677150, GSM677151, GSM677152, GSM677153, GSM677154, GSM677155, GSM677156, GSM677157, GSM677158, GSM677159, GSM677174, GSM677175, GSM677176, GS
Perturbed SamplesGSM677118, GSM677119, GSM677120, GSM677121, GSM677122, GSM677123, GSM677124, GSM677125, GSM677141, GSM677142, GSM677143, GSM677144, GSM677145, GSM677146, GSM677147, GSM677167, GSM677168, GSM677169, GSM677170, GSM677171, GSM677172, GSM677173
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE27383
Gene Expression Omnibus
Marked Reduction of AKT1 Expression and Deregulation of AKT1-associated Pathways in Peripheral Blood Mononuclear Cells of Schizophrenia Patients
14
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