Small molecules which mimic Alzheimer's disease
Canned Analysis
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General Information
AccessionDCA00010390
TitleSmall molecules which mimic Alzheimer's disease
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the Alzheimer's disease gene expression signature in the entorhinal cortex neurons cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1bbfee467bea600fb82ce
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsaulc07
CREEDS IDdz:592
Cell Typeentorhinal cortex neurons
DO IDDOID:10652
Disease NameAlzheimer's disease
Organismhuman
UMLS CUIC0002395
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM107522, GSM107524, GSM107526, GSM107528, GSM107530, GSM107532, GSM107534, GSM107536, GSM107538, GSM107540
Perturbed SamplesGSM107523, GSM107525, GSM107527, GSM107529, GSM107531, GSM107533, GSM107535, GSM107537, GSM107539, GSM107541
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4757
Gene Expression Omnibus
Alzheimer's disease: neurofibrillary tangles
7
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