Small molecules which reverse amyotrophic lateral sclerosis
Canned Analysis
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General Information
AccessionDCA00010529
TitleSmall molecules which reverse amyotrophic lateral sclerosis
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the amyotrophic lateral sclerosis gene expression signature in the ventral spinal cord, motor neurons cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1b711e467bea600fb8060
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdz:682
Cell Typeventral spinal cord, motor neurons
DO IDDOID:332
Disease Nameamyotrophic lateral sclerosis
Organismrat
UMLS CUIC0002736
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM181541, GSM181542, GSM181543, GSM181544, GSM181545
Perturbed SamplesGSM181537, GSM181538, GSM181539, GSM181540
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE7493
Gene Expression Omnibus
SOD1-G93A mutant model of amyotrophic lateral sclerosis: embryonic motor neurons
7
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