Small molecules which mimic precursor B lymphoblastic lymphoma/leukemia
Canned Analysis
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General Information
AccessionDCA00010726
TitleSmall molecules which mimic precursor B lymphoblastic lymphoma/leukemia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the precursor B lymphoblastic lymphoma/leukemia gene expression signature in the AT2 E/R positive BCP ALL cell line (following E/R -ETV6/RUNX1- knockdown) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ba64e467bea600fb8202
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:803
Cell TypeAT2 E/R positive BCP ALL cell line (following E/R -ETV6/RUNX1- knockdown)
DO IDDOID:7061
Disease Nameprecursor B lymphoblastic lymphoma/leukemia
Organismhuman
UMLS CUIC0862030
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM734473, GSM734475
Perturbed SamplesGSM734474, GSM734476
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29639
Gene Expression Omnibus
Leukemia-specific fusion gene ETV6/RUNX1 knockdown effect on ETV6/RUNX1-positive, B-cell precursor acute lymphoblastic leukemia cell lines
14
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