Small molecules which reverse systemic lupus erythematosus
Canned Analysis
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General Information
AccessionDCA00010739
TitleSmall molecules which reverse systemic lupus erythematosus
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the systemic lupus erythematosus gene expression signature in the Connective Tissue in Joints cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1c4fae467bea600fb8730
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgswaminath
CREEDS IDdz:816
Cell TypeConnective Tissue in Joints
DO IDDOID:9074
Disease Namesystemic lupus erythematosus
Organismhuman
UMLS CUIC0024141
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1509709, GSM1509710, GSM1509711, GSM1509712, GSM1509713, GSM1509714, GSM1509715, GSM1509716, GSM1509717, GSM1509718, GSM1509719, GSM1509720, GSM1509721, GSM1509722, GSM1509723, GSM1509724
Perturbed SamplesGSM1509610, GSM1509611, GSM1509612, GSM1509613, GSM1509614, GSM1509615, GSM1509616, GSM1509617, GSM1509618, GSM1509619, GSM1509620, GSM1509621, GSM1509622, GSM1509623, GSM1509624, GSM1509625
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE61635
Gene Expression Omnibus
Gene expression in RNP autoantibody+ systemic lupus erythematosus (SLE) patient blood
7
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