Small molecules which reverse adrenoleukodystrophy
Canned Analysis
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General Information
AccessionDCA00010825
TitleSmall molecules which reverse adrenoleukodystrophy
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the adrenoleukodystrophy gene expression signature in the Induced pluripotent stem cells -iPSC- (derived from childhood cerebral adrenoleukodystrophy patient dermal fibroblasts) and healthy fibroblasts cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1c5ebe467bea600fb87a8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:865
Cell TypeInduced pluripotent stem cells -iPSC- (derived from childhood cerebral adrenoleukodystrophy patient dermal fibroblasts) and healthy fibroblasts
DO IDDOID:10588
Disease Nameadrenoleukodystrophy
Organismhuman
UMLS CUIC0162309
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM847093, GSM847094, GSM847095, GSM847096, GSM847097, GSM847098, GSM847099, GSM847100
Perturbed SamplesGSM847101, GSM847102, GSM847103, GSM847104, GSM847105
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE34309
Gene Expression Omnibus
Childhood cerebral adrenoleukodystrophy patient-specific iPSC model
14
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