Small molecules which reverse relapsing-remitting multiple sclerosis
Canned Analysis
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General Information
AccessionDCA00010851
TitleSmall molecules which reverse relapsing-remitting multiple sclerosis
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the relapsing-remitting multiple sclerosis gene expression signature in the CD4+ T cells Lymphocytes (sorted from PBMCs from monozygotic twin pairs discordant for RRMS) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1c803e467bea600fb88b4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:879
Cell TypeCD4+ T cells Lymphocytes (sorted from PBMCs from monozygotic twin pairs discordant for RRMS)
DO IDDOID:2378
Disease Namerelapsing-remitting multiple sclerosis
Organismhuman
UMLS CUIC0751967
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM413790, GSM413792, GSM413795, GSM413796
Perturbed SamplesGSM413791, GSM413793, GSM413794, GSM413797
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16461
Gene Expression Omnibus
Identical twins discordant for Multiple sclerosis: CD4+ and CD8+ T cells
7
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