Small molecules which mimic familial hypercholesterolemia
Canned Analysis
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General Information
AccessionDCA00010882
TitleSmall molecules which mimic familial hypercholesterolemia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the familial hypercholesterolemia gene expression signature in the T lymphocytes - Heterozygous FH cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1b84ee467bea600fb80fa
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:907
Cell TypeT lymphocytes - Heterozygous FH
DO IDDOID:13810
Disease Namefamilial hypercholesterolemia
Organismhuman
UMLS CUIC0020445
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM141552, GSM141553, GSM141554, GSM141555, GSM141556, GSM141557, GSM141558, GSM141559, GSM141560, GSM141561, GSM141562, GSM141563, GSM141564
Perturbed SamplesGSM141543, GSM141546, GSM141548, GSM141549, GSM141550, GSM141551, GSM141566
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6088
Gene Expression Omnibus
Familial hypercholesterolemia and atherosclerosis: T lymphocytes
14
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