Small molecules which reverse familial hypercholesterolemia
Canned Analysis
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General Information
AccessionDCA00010887
TitleSmall molecules which reverse familial hypercholesterolemia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the familial hypercholesterolemia gene expression signature in the Monocytes - Heterozygous FH cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1b842e467bea600fb80f4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:909
Cell TypeMonocytes - Heterozygous FH
DO IDDOID:13810
Disease Namefamilial hypercholesterolemia
Organismhuman
UMLS CUIC0020445
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM140244, GSM140245, GSM140246, GSM140247, GSM140248, GSM140249, GSM140250, GSM140251, GSM140252, GSM140253, GSM140254, GSM140255, GSM140256
Perturbed SamplesGSM140232, GSM140236, GSM140239, GSM140240, GSM140241, GSM140257
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE6054
Gene Expression Omnibus
Familial hypercholesterolemia and atherosclerosis: monocytes
14
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