Small molecules which mimic Imatinib treatment
Canned Analysis
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General Information
AccessionDCA00011796
TitleSmall molecules which mimic Imatinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Imatinib treatment in the K562 leukemia cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e7bce467bea600fb9710
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsaulc07
CREEDS IDdrug:2457
Cell TypeK562 leukemia cell line
Drug NameImatinib
DrugBank IDDB00619
Organismhuman
PubChem CID5291
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM34927, GSM34928, GSM34929
Perturbed SamplesGSM34930, GSM34931, GSM34932
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1922
Gene Expression Omnibus
Imatinib effect on K562 leukemia cell line (VIII)
56
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