Small molecules which reverse Imatinib treatment
Canned Analysis
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General Information
AccessionDCA00011801
TitleSmall molecules which reverse Imatinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Imatinib treatment in the K562 leukemia cell line (VII) - 24 Hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d8ffe467bea600fb9096
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2513
Cell TypeK562 leukemia cell line (VII) - 24 Hours
Drug NameImatinib
DrugBank IDDB00619
Organismhuman
PubChem CID5291
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM34933, GSM34934, GSM34935
Perturbed SamplesGSM34936, GSM34937, GSM34938
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1922
Gene Expression Omnibus
Imatinib effect on K562 leukemia cell line (VIII)
56
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