Small molecules which reverse Celecoxib treatment
Canned Analysis
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General Information
AccessionDCA00011815
TitleSmall molecules which reverse Celecoxib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Celecoxib treatment in the colon cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1daade467bea600fb9152
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgaribr01
CREEDS IDdrug:3296
Cell Typecolon
Drug NameCelecoxib
DrugBank IDDB00482
Organismhuman
PubChem CID2662
SMILES IDCC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM283131, GSM283133, GSM283137, GSM283139, GSM283140
Perturbed SamplesGSM283136, GSM283138, GSM283142, GSM283145, GSM283147
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11237
Gene Expression Omnibus
Cyclooxygenase-2 inhibitor celecoxib effect on colorectal adenocarcinoma
19
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