Small molecules which mimic Sirolimus treatment
Canned Analysis
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General Information
AccessionDCA00011816
TitleSmall molecules which mimic Sirolimus treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Sirolimus treatment in the T cell lymphoblastic leukemia cell line CEM-c1 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e7ebe467bea600fb9724
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsaulc07
CREEDS IDdrug:2459
Cell TypeT cell lymphoblastic leukemia cell line CEM-c1
Drug NameSirolimus
DrugBank IDDB00877
Organismhuman
SMILES IDCO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H]([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H](CC[C@H]2C)C[C@H](OC)/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C1)C)/C)O)OC)C)C)/C)C
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM136055, GSM136056, GSM136057
Perturbed SamplesGSM136064, GSM136065, GSM136066
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5824
Gene Expression Omnibus
Rapamycin effect on a glucorticoid-resistant T cell lymphoblastic leukemia cell line: time course
7
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