Small molecules which mimic Monuron treatment
Canned Analysis
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General Information
AccessionDCA00011828
TitleSmall molecules which mimic Monuron treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Monuron treatment in the rat proximal renal tubule cell line (NRK-52E), 24h treatment cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e8bfe467bea600fb9782
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDdrug:2465
Cell Typerat proximal renal tubule cell line (NRK-52E), 24h treatment
Drug NameMonuron
Organismrat
PubChem CID8800
SMILES IDCN(C)C(=O)NC1=CC=C(C=C1)Cl
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1239934, GSM1239935, GSM1239936
Perturbed SamplesGSM1239931, GSM1239932, GSM1239933
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE51163
Gene Expression Omnibus
Expression data from NRK-52E cells treated with monuron for 6h, 24h and 72h and rats exposed to monuron for 72h.
35
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