Small molecules which reverse Haloperidol treatment
Canned Analysis
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General Information
AccessionDCA00011839
TitleSmall molecules which reverse Haloperidol treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Haloperidol treatment in the brain, 12 week treatment cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e149e467bea600fb943e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdrug:2466
Cell Typebrain, 12 week treatment
Drug NameHaloperidol
DrugBank IDDB00502
Organismmouse
PubChem CID3559
SMILES IDC1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM148677, GSM148678, GSM148679, GSM148680, GSM148681, GSM148682, GSM148683, GSM148684, GSM148685, GSM148686
Perturbed SamplesGSM148667, GSM148668, GSM148669, GSM148670, GSM148671, GSM148672, GSM148673, GSM148674, GSM148675, GSM148676
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6467
Gene Expression Omnibus
Antipsychotic agents clozapine and haloperidol effects on the brain (II)
14
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