Small molecules which mimic Clozapine treatment
Canned Analysis
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General Information
AccessionDCA00011840
TitleSmall molecules which mimic Clozapine treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Clozapine treatment in the brain, 4 week treatment cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e125e467bea600fb942c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdrug:2469
Cell Typebrain, 4 week treatment
Drug NameClozapine
DrugBank IDDB00363
Organismmouse
PubChem CID2818
SMILES IDCN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM149811, GSM149812, GSM149813
Perturbed SamplesGSM149805, GSM149806, GSM149807
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6511
Gene Expression Omnibus
Antipsychotic agents clozapine and haloperidol effects on the brain (I)
14
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