Small molecules which mimic Cocaine treatment
Canned Analysis
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General Information
AccessionDCA00011844
TitleSmall molecules which mimic Cocaine treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Cocaine treatment in the midbrain cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e68ee467bea600fb968c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdrug:2472
Cell Typemidbrain
Drug NameCocaine
Organismhuman
PubChem CID446220
SMILES IDCN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1324893, GSM1324894, GSM1324895, GSM1324899, GSM1324900, GSM1324901, GSM1324905, GSM1324906, GSM1324907, GSM1324911, GSM1324912, GSM1324913, GSM1324917, GSM1324918, GSM1324919, GSM1324923, GSM1324924, GSM1324925, GSM1324929, GSM1324930, GSM1324931, GSM
Perturbed SamplesGSM1324896, GSM1324897, GSM1324898, GSM1324902, GSM1324903, GSM1324904, GSM1324908, GSM1324909, GSM1324910, GSM1324914, GSM1324915, GSM1324916, GSM1324920, GSM1324921, GSM1324922, GSM1324926, GSM1324927, GSM1324928, GSM1324932, GSM1324933, GSM1324934, GSM
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54839
Gene Expression Omnibus
Cocaine abuse effect on the midbrain
7
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