Small molecules which reverse Metformin treatment
Canned Analysis
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General Information
AccessionDCA00011869
TitleSmall molecules which reverse Metformin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Metformin treatment in the Human primary fibroblasts (IMR90) stably expressing H-RasV12 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d76fe467bea600fb8fe2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdrug:2483
Cell TypeHuman primary fibroblasts (IMR90) stably expressing H-RasV12
Drug NameMetformin
DrugBank IDDB00331
Organismhuman
PubChem CID4091
SMILES IDCN(C)C(=N)N=C(N)N
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM831051, GSM831052, GSM831053
Perturbed SamplesGSM831054, GSM831055, GSM831056
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE33612
Gene Expression Omnibus
Expression data from human primary fibroblasts (IMR90) stably expressing H-RasV12 and treated with Metformin or vehicle
7
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