Small molecules which reverse Atorvastatin treatment
Canned Analysis
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General Information
AccessionDCA00011871
TitleSmall molecules which reverse Atorvastatin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Atorvastatin treatment in the Primary umbilical vein endothelial cell cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d739e467bea600fb8fca
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdrug:2484
Cell TypePrimary umbilical vein endothelial cell
Drug NameAtorvastatin
DrugBank IDDB01076
Organismhuman
SMILES IDOC(CC(CC(=O)[O-])O)CCn1c(C(C)C)c(c(c1c1ccc(cc1)F)c1ccccc1)C(=O)Nc1ccccc1
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM46388, GSM46389
Perturbed SamplesGSM46394, GSM46395
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2450
Gene Expression Omnibus
Immortalized endothelial cell line response to atorvastatin
7
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