Small molecules which mimic Hydroxyzine treatment
Canned Analysis
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General Information
AccessionDCA00011872
TitleSmall molecules which mimic Hydroxyzine treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Hydroxyzine treatment in the CD4+ cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d2a2e467bea600fb8dc0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvcogliani
CREEDS IDdrug:2485
Cell TypeCD4+
Drug NameHydroxyzine
DrugBank IDDB00557
Organismhuman
PubChem CID3658
SMILES IDC1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM788303, GSM788304, GSM788305, GSM788306, GSM788307, GSM788308, GSM788309, GSM788310
Perturbed SamplesGSM788311, GSM788312, GSM788313, GSM788314, GSM788315, GSM788316, GSM788317, GSM788318
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE31773
Gene Expression Omnibus
Severe asthma: circulating CD4+ and CD8+ T-cells
33
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