Small molecules which mimic Dexamethasone treatment
Canned Analysis
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General Information
AccessionDCA00011878
TitleSmall molecules which mimic Dexamethasone treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Dexamethasone treatment in the glucocorticoid (GC)-resistant lymphoblastic leukemia CEM-C7H2 T-ALL cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ea4ee467bea600fb982e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortimkenny92
CREEDS IDdrug:2488
Cell Typeglucocorticoid (GC)-resistant lymphoblastic leukemia CEM-C7H2 T-ALL cell line
Drug NameDexamethasone
DrugBank IDDB01234
Organismhuman
PubChem CID5743
SMILES IDCC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM550942, GSM550943, GSM550944, GSM550945, GSM550946, GSM550947
Perturbed SamplesGSM550954, GSM550955, GSM550956, GSM550957, GSM550958, GSM550959
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE22152
Gene Expression Omnibus
Dexamethasone effect on glucocorticoid-resistant and -sensitive lymphoblastic leukemia cell lines
7
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