Small molecules which reverse 1,25 dihydroxyvitamin d treatment
Canned Analysis
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General Information
AccessionDCA00011887
TitleSmall molecules which reverse 1,25 dihydroxyvitamin d treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by 1,25 dihydroxyvitamin d treatment in the RWPE1 cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ec58e467bea600fb9918
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2493
Cell TypeRWPE1 cells
Drug Name1,25 dihydroxyvitamin d
Organismhuman
PubChem CID5280453
SMILES IDCC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM400051, GSM400052, GSM400053, GSM400054, GSM400059, GSM400060, GSM400061, GSM400062, GSM400067, GSM400068, GSM400069, GSM400070
Perturbed SamplesGSM400055, GSM400056, GSM400057, GSM400058, GSM400063, GSM400064, GSM400065, GSM400066, GSM400071, GSM400072, GSM400073, GSM400074
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE15947
Gene Expression Omnibus
1,25 dihydroxyvitamin D effect on prostate epithelial cell line RWPE1: time course
28
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