Small molecules which reverse Vemurafenib treatment
Canned Analysis
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General Information
AccessionDCA00011897
TitleSmall molecules which reverse Vemurafenib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Vemurafenib treatment in the BRAFV600E A375 human melanoma cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ec6ae467bea600fb9920
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2495
Cell TypeBRAFV600E A375 human melanoma cells
Drug NameVemurafenib
Organismhuman
PubChem CID42611257
SMILES IDCCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1052615, GSM1052616, GSM1052617
Perturbed SamplesGSM1052618, GSM1052619, GSM1052620
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42872
Gene Expression Omnibus
Oncogenic BRAF harboring melanoma cell line response to BRAF inhibition
12
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