Small molecules which reverse Tamoxifen treatment
Canned Analysis
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General Information
AccessionDCA00011899
TitleSmall molecules which reverse Tamoxifen treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Tamoxifen treatment in the LY2 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dc77e467bea600fb921e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsaulc07
CREEDS IDdrug:2496
Cell TypeLY2
Drug NameTamoxifen
DrugBank IDDB00675
Organismhuman
PubChem CID2733526
SMILES IDCCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM709765, GSM709771, GSM709772, GSM709775
Perturbed SamplesGSM709767, GSM709769
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE28645
Gene Expression Omnibus
Tamoxifen effect on SRC-1-deficient endocrine-resistant breast cancer cell line LY2
28
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