Small molecules which reverse Isotretinoin treatment
Canned Analysis
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General Information
AccessionDCA00011905
TitleSmall molecules which reverse Isotretinoin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Isotretinoin treatment in the skin cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d4fde467bea600fb8eca
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2498
Cell Typeskin cells
Drug NameIsotretinoin
Organismhuman
PubChem CID5282379
SMILES IDCC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM263921, GSM263923, GSM263925, GSM263927, GSM263929, GSM263931
Perturbed SamplesGSM263922, GSM263924, GSM263926, GSM263928, GSM263930, GSM263932
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE10433
Gene Expression Omnibus
13-cis retinoic acid effect on skin
7
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