Small molecules which reverse Methylphenidate treatment
Canned Analysis
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General Information
AccessionDCA00011907
TitleSmall molecules which reverse Methylphenidate treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Methylphenidate treatment in the brain cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d50fe467bea600fb8ed2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsaulc07
CREEDS IDdrug:2499
Cell Typebrain
Drug NameMethylphenidate
DrugBank IDDB00422
Organismmouse
PubChem CID4158
SMILES IDCOC(=O)C(C1CCCCN1)C2=CC=CC=C2
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM831337, GSM831338, GSM831339
Perturbed SamplesGSM831340, GSM831341, GSM831342
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE33619
Gene Expression Omnibus
Methylphenidate effect on substantia nigra: dose response
7
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