Small molecules which mimic Plx4720 treatment
Canned Analysis
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General Information
AccessionDCA00011926
TitleSmall molecules which mimic Plx4720 treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Plx4720 treatment in the HT29 3D culture cell - Day 8 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1db3ae467bea600fb9190
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2507
Cell TypeHT29 3D culture cell - Day 8
Drug NamePlx4720
Organismhuman
PubChem CID24180719
SMILES IDCCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1229359, GSM1229365
Perturbed SamplesGSM1229360, GSM1229366
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50791
Gene Expression Omnibus
B-Raf inhibitors induce epithelial differentiation in BRAF mutant colorectal cancer cells
43
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