Small molecules which reverse Olanzapine treatment
Canned Analysis
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General Information
AccessionDCA00011935
TitleSmall molecules which reverse Olanzapine treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Olanzapine treatment in the brain frontal cortex tissue cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d8ede467bea600fb908e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2511
Cell Typebrain frontal cortex tissue
Drug NameOlanzapine
Organismrat
PubChem CID4585
SMILES IDCC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM48559, GSM48577, GSM48578, GSM48579
Perturbed SamplesGSM48580, GSM48581, GSM48582, GSM48583
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2547
Gene Expression Omnibus
Antipsychotic agent olanzapine effect on the brain frontal cortex
7
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