Small molecules which reverse Rituximab treatment
Canned Analysis
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General Information
AccessionDCA00011937
TitleSmall molecules which reverse Rituximab treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Rituximab treatment in the synovial knee tissue cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e332e467bea600fb9516
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2514
Cell Typesynovial knee tissue
Drug NameRituximab
DrugBank IDDB00073
Organismhuman
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM607508, GSM609031, GSM609033, GSM609035, GSM609037, GSM609386, GSM609388, GSM609390, GSM609392, GSM609394, GSM609396, GSM609398
Perturbed SamplesGSM607509, GSM609032, GSM609034, GSM609036, GSM609038, GSM609387, GSM609389, GSM609391, GSM609393, GSM609395, GSM609397, GSM609399
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24742
Gene Expression Omnibus
Rheumatoid arthritic synovium response to rituximab
12
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