Small molecules which mimic Imatinib (glivec) treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00011938
TitleSmall molecules which mimic Imatinib (glivec) treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Imatinib (glivec) treatment in the Philadelphia chromosome positive CML CD34+ cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e2cee467bea600fb94e8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdrug:2518
Cell TypePhiladelphia chromosome positive CML CD34+ cells
Drug NameImatinib (glivec)
Organismhuman
PubChem CID123596
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM307000, GSM307012, GSM307013, GSM307018, GSM307020, GSM307023
Perturbed SamplesGSM307028, GSM307030, GSM307031, GSM307032, GSM307053, GSM307072
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12211
Gene Expression Omnibus
Chronic myelogenous leukemia response to imatinib: Philadelphia chromosome positive CD34+ cells
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.