Small molecules which mimic Imatinib treatment
Canned Analysis
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General Information
AccessionDCA00011940
TitleSmall molecules which mimic Imatinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Imatinib treatment in the Chronic myelogenous leukemia CD34+ cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1df71e467bea600fb936c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2521
Cell TypeChronic myelogenous leukemia CD34+ cells
Drug NameImatinib
DrugBank IDDB00619
Organismhuman
PubChem CID5291
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM23406, GSM23407, GSM23408, GSM23409, GSM23410, GSM23411
Perturbed SamplesGSM23412, GSM23414, GSM23415, GSM23416, GSM23418, GSM23420, GSM23421, GSM23423
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1418
Gene Expression Omnibus
Imatinib effects on chronic myelogenous leukemia CD34+ cells
7
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