Small molecules which reverse Imatinib treatment
Canned Analysis
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General Information
AccessionDCA00011945
TitleSmall molecules which reverse Imatinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Imatinib treatment in the Bach2 wildtype pre-B ALL cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1eb1de467bea600fb9888
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2523
Cell TypeBach2 wildtype pre-B ALL cells
Drug NameImatinib
DrugBank IDDB00619
Organismmouse
PubChem CID5291
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM766000, GSM766017, GSM766018
Perturbed SamplesGSM766019, GSM766020, GSM766021
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE30883
Gene Expression Omnibus
Role and function of Bach2 in BCR-ABL1 driven pre-B ALL
14
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