Small molecules which reverse Nilotinib treatment
Canned Analysis
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General Information
AccessionDCA00011951
TitleSmall molecules which reverse Nilotinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Nilotinib treatment in the K562 cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1df90e467bea600fb937a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2528
Cell TypeK562 cells
Drug NameNilotinib
DrugBank IDDB04868
Organismhuman
PubChem CID644241
SMILES IDCC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM487691, GSM487692, GSM487693, GSM487694
Perturbed SamplesGSM487683, GSM487684, GSM487685, GSM487686
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19567
Gene Expression Omnibus
Imatinib and Nilotinib induced molecular changes in Philadelphia chromosome-positive Chronic Myelogenous Leukemia
14
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