Small molecules which mimic Azacitidine treatment
Canned Analysis
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General Information
AccessionDCA00011958
TitleSmall molecules which mimic Azacitidine treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Azacitidine treatment in the A549 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dd3ae467bea600fb9274
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:2534
Cell TypeA549
Drug NameAzacitidine
DrugBank IDDB00928
Organismhuman
PubChem CID9444
SMILES IDC1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM720475, GSM720476
Perturbed SamplesGSM720477, GSM720478
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE29077
Gene Expression Omnibus
Expression data comparing azacitidine and decitabine in non-small cell lung cancer lines
84
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