Small molecules which mimic Methotrexate treatment
Canned Analysis
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General Information
AccessionDCA00011984
TitleSmall molecules which mimic Methotrexate treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Methotrexate treatment in the PBMC cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d3a2e467bea600fb8e30
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatoralanstern
CREEDS IDdrug:2541
Cell TypePBMC
Drug NameMethotrexate
DrugBank IDDB00563
Organismhuman
PubChem CID126941
SMILES IDCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM580950, GSM580952, GSM580954, GSM580956, GSM580958, GSM580960, GSM580962, GSM580964, GSM580966, GSM580968, GSM580970
Perturbed SamplesGSM580951, GSM580953, GSM580955, GSM580957, GSM580959, GSM580961, GSM580963, GSM580965, GSM580967, GSM580969, GSM580971
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE23687
Gene Expression Omnibus
Methotrexate effect on SPARKS CHARMS juvenile idiopathic arthritis cohort: peripheral blood mononuclear cells
7
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