Small molecules which mimic Temozolomide treatment
Canned Analysis
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General Information
AccessionDCA00011998
TitleSmall molecules which mimic Temozolomide treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Temozolomide treatment in the U87 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1eef2e467bea600fb9a3e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAliDot
CREEDS IDdrug:2555
Cell TypeU87
Drug NameTemozolomide
DrugBank IDDB00853
Organismhuman
PubChem CID5394
SMILES IDCN1C(=O)N2C=NC(=C2N=N1)C(=O)N
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1062690, GSM1062691
Perturbed SamplesGSM1062692, GSM1062693
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE43452
Gene Expression Omnibus
Glioblastoma cells response to Focal Adhesion Kinase Inhibitor Y15 and Temozolomide
21
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