Small molecules which mimic Plx4032 treatment
Canned Analysis
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General Information
AccessionDCA00012004
TitleSmall molecules which mimic Plx4032 treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Plx4032 treatment in the COLO829 human melanoma cell line-MITF Knockdown (BRAFV600E mutated) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ed2be467bea600fb9976
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2558
Cell TypeCOLO829 human melanoma cell line-MITF Knockdown (BRAFV600E mutated)
Drug NamePlx4032
DrugBank IDDB05238
Organismhuman
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1225717, GSM1225718
Perturbed SamplesGSM1225719, GSM1225720
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE50649
Gene Expression Omnibus
COLO829 treatment with PLX4032 and/or MITF knockdown
14
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