Small molecules which mimic Vemurafenib treatment
Canned Analysis
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General Information
AccessionDCA00012014
TitleSmall molecules which mimic Vemurafenib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Vemurafenib treatment in the SK-MEL-28 melanoma cell line (vemurafenib sensitive cell line) - 6 Hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d64ae467bea600fb8f5c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2563
Cell TypeSK-MEL-28 melanoma cell line (vemurafenib sensitive cell line) - 6 Hours
Drug NameVemurafenib
DrugBank IDDB08881
Organismhuman
SMILES IDCCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c1c[nH]c2c1cc(cn2)c1ccc(cc1)Cl)F
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM919367, GSM919368, GSM919369
Perturbed SamplesGSM919373, GSM919374, GSM919375
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE37441
Gene Expression Omnibus
Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.
42
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