Small molecules which reverse Deferasirox treatment
Canned Analysis
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General Information
AccessionDCA00012031
TitleSmall molecules which reverse Deferasirox treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Deferasirox treatment in the K562 (human myeloid leukemia cells) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d4ace467bea600fb8ea6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:2571
Cell TypeK562 (human myeloid leukemia cells)
Drug NameDeferasirox
DrugBank IDDB01609
Organismhuman
PubChem CID5493381
SMILES IDC1=CC(=C2NC(=C3C=CC=CC3=O)N(N2)C4=CC=C(C=C4)C(=O)O)C(=O)C=C1
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM296608, GSM296609
Perturbed SamplesGSM296612, GSM296613
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE11670
Gene Expression Omnibus
Deferasirox effect on leukemia cell line: dose response
19
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