Small molecules which mimic Doxycycline treatment
Canned Analysis
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General Information
AccessionDCA00012034
TitleSmall molecules which mimic Doxycycline treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Doxycycline treatment in the C33KD2 cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d498e467bea600fb8e9c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:2573
Cell TypeC33KD2 cells
Drug NameDoxycycline
DrugBank IDDB00254
Organismhuman
PubChem CID5281011
SMILES IDCC1C2C(C3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM287516, GSM288241, GSM288243
Perturbed SamplesGSM288248, GSM288249, GSM288260
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11422
Gene Expression Omnibus
Genes differentially expressed upon CHD8 knockdown
7
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