Small molecules which reverse Fgfr-specific pd173074 inhibitor treatment
Canned Analysis
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General Information
AccessionDCA00012047
TitleSmall molecules which reverse Fgfr-specific pd173074 inhibitor treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Fgfr-specific pd173074 inhibitor treatment in the human multiple myeloma cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e52fe467bea600fb95f6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorjustinenoel
CREEDS IDdrug:3244
Cell Typehuman multiple myeloma cell line
Drug NameFgfr-specific pd173074 inhibitor
Organismhuman
PubChem CID1401
SMILES IDCCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1267153, GSM1267154, GSM1267155
Perturbed SamplesGSM1267156, GSM1267157, GSM1267158
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52452
Gene Expression Omnibus
Fibroblast growth factor receptor inhibition effect on malignant urothelial cells deficient in TGF-activated kinase 1
33
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