Small molecules which reverse Lapatinib treatment
Canned Analysis
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General Information
AccessionDCA00012051
TitleSmall molecules which reverse Lapatinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Lapatinib treatment in the BT474 (lapatinib-sensitive) HER2+ breast cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e21ae467bea600fb949a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2580
Cell TypeBT474 (lapatinib-sensitive) HER2+ breast cancer cells
Drug NameLapatinib
DrugBank IDDB01259
Organismhuman
PubChem CID208908
SMILES IDCS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM799168, GSM799169, GSM799170
Perturbed SamplesGSM799171, GSM799172, GSM799173
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16179
Gene Expression Omnibus
Lapatinib-resistant HER2-positive breast tumor cells
21
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