Small molecules which reverse Foretinib treatment
Canned Analysis
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General Information
AccessionDCA00012055
TitleSmall molecules which reverse Foretinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Foretinib treatment in the BT474-J4 (acquired lapatinib-resistance) HER2+ breast cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e77fe467bea600fb96f6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2582
Cell TypeBT474-J4 (acquired lapatinib-resistance) HER2+ breast cancer cells
Drug NameForetinib
Organismhuman
PubChem CID42642645
SMILES IDCOC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM799174, GSM799175, GSM799176
Perturbed SamplesGSM799177, GSM799178, GSM799179
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16179
Gene Expression Omnibus
Lapatinib-resistant HER2-positive breast tumor cells
21
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