Small molecules which reverse Lapatinib treatment
Canned Analysis
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General Information
AccessionDCA00012061
TitleSmall molecules which reverse Lapatinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Lapatinib treatment in the lapatinib-resistant ErbB2-positive cells treated with 0.1 uM lapatinib cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e1ece467bea600fb9486
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2585
Cell Typelapatinib-resistant ErbB2-positive cells treated with 0.1 uM lapatinib
Drug NameLapatinib
DrugBank IDDB01259
Organismhuman
PubChem CID208908
SMILES IDCS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM940882, GSM940883, GSM940884
Perturbed SamplesGSM940885, GSM940886, GSM940887
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE38376
Gene Expression Omnibus
Lapatinib effect on lapatinib-resistant ErbB2-positive cell line: dose response
42
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