Small molecules which reverse Aplidin treatment
Canned Analysis
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General Information
AccessionDCA00012091
TitleSmall molecules which reverse Aplidin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Aplidin treatment in the diffuse large B cell lymphoma SKI-DLCL cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e566e467bea600fb960e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDdrug:2598
Cell Typediffuse large B cell lymphoma SKI-DLCL cells
Drug NameAplidin
Organismhuman
PubChem CID56928089
SMILES IDCCC(C)C1C(CC(=O)OC(C(=O)C(C(=O)NC(C(=O)N2CCCC2C(=O)N(C(C(=O)OC(C(C(=O)N1)NC(=O)C(CC(C)C)N(C)C(=O)C3CCCN3C(=O)C(=O)C)C)CC4=CC=C(C=C4)OC)C)CC(C)C)C)C(C)C)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM132917, GSM132918, GSM132920
Perturbed SamplesGSM132941, GSM132944, GSM132947
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5681
Gene Expression Omnibus
Aplidin and cytarabine effect on diffuse large B cell lymphoma cell line
14
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