Small molecules which mimic Methotrexate treatment
Canned Analysis
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General Information
AccessionDCA00012094
TitleSmall molecules which mimic Methotrexate treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Methotrexate treatment in the granulocyte cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ee16e467bea600fb99de
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:2600
Cell Typegranulocyte
Drug NameMethotrexate
DrugBank IDDB00563
Organismhuman
PubChem CID126941
SMILES IDCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1025129, GSM1025130, GSM1025131, GSM1025132, GSM1025133, GSM1025134, GSM1025135, GSM1025136, GSM1025137, GSM1025138, GSM1025139, GSM1025140, GSM1025141
Perturbed SamplesGSM1025142, GSM1025143, GSM1025144, GSM1025145, GSM1025146, GSM1025147, GSM1025148, GSM1025149, GSM1025150, GSM1025151
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41831
Gene Expression Omnibus
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