Small molecules which mimic Heroin treatment
Canned Analysis
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General Information
AccessionDCA00012120
TitleSmall molecules which mimic Heroin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Heroin treatment in the striatum, day 15 withdrawal cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e5d1e467bea600fb963c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDdrug:2622
Cell Typestriatum, day 15 withdrawal
Drug NameHeroin
DrugBank IDDB01452
Organismmouse
PubChem CID5462328
SMILES IDCC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM751170, GSM751205, GSM751229
Perturbed SamplesGSM751164, GSM751199, GSM751217
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE30305
Gene Expression Omnibus
Transcriptional effects of chronic heroin and methamphetamine treatment in the mouse striatum
63
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