Small molecules which mimic Dapt treatment
Canned Analysis
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General Information
AccessionDCA00012178
TitleSmall molecules which mimic Dapt treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Dapt treatment in the Aortic valve interstitial cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d886e467bea600fb905c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:2648
Cell TypeAortic valve interstitial cells
Drug NameDapt
Organismrat
PubChem CID5311272
SMILES IDCC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM786185, GSM786186, GSM786187
Perturbed SamplesGSM786182, GSM786183, GSM786184
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE31668
Gene Expression Omnibus
Notch1 signaling inhibition effect on aortic valve interstitial cells
7
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